Rh(III)-Catalyzed [4 + 1] Annulation of Benzamides with CF₃-Ynones as a C₁ Synthon: Access to CF₃-Containing Isoindolinones.

Wentai Xue; Shuang Wu; Hongqing Xie; Peidong Yang; Chenggang Shan; Fei Zhao; Qiu Li; Xiuwen Jia

doi:10.1021/acs.orglett.6c01974

June 24, 2026

Rh(III)-Catalyzed [4 + 1] Annulation of Benzamides with CF₃-Ynones as a C₁ Synthon: Access to CF₃-Containing Isoindolinones.

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Key Points

To develop a protocol for the rhodium(III)-catalyzed annulation of benzamides with CF3-ynones for synthesizing isoindolinones.
Utilized rhodium(III) as a catalyst for the reaction between benzamides and CF3-ynones.
Assessed various reaction conditions for chemo- and regioselectivity.
Evaluated yields across a range of substrates with different functional groups.
Achieved excellent chemo- and regioselectivity with the proposed method.
Produced isoindolinones in good to high yields, demonstrating broad functional group tolerance.

Implication

This trial explores rhodium-catalyzed reactions to create CF3-containing isoindolinones, suggesting new synthetic routes.

Abstract

-substituted isoindolinones. This protocol is characterized by excellent chemo- and regioselectivities, a broad substrate scope, good functional group tolerance, and good to high yields.

Discussion

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Cite This Study

Xue et al. (2026) studied this question.

synapsesocial.com/papers/6a3e1a93030ad1a9b3092fdc https://doi.org/10.1021/acs.orglett.6c01974

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Rh(III)-Catalyzed [4 + 1] Annulation of Benzamides with CF₃-Ynones as a C₁ Synthon: Access to CF₃-Containing Isoindolinones.

Key Points

Implication

Abstract

Discussion

Cite This Study

Rh(III)-Catalyzed [4 + 1] Annulation of Benzamides with CF₃-Ynones as a C₁ Synthon: Access to CF₃-Containing Isoindolinones.

Key Points

Implication

Abstract

Discussion

Cite This Study

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