Reports successful synthesis of alkenyl difluorocyclopropenes from difluorocarbene and enynes, suggesting efficient methods for complex organic compounds.
The chemoselective [2+1] cycloaddition of difluorocarbene with conjugated enynes has been achieved. Using TMSCF2Br as the difluorocarbene precursor in the presence of a catalytic amount of n-Bu4N+Br–, the reaction proceeded smoothly in THF at 110 °C, affording a series of alkenyl-substituted difluorocyclopropenes. Subsequently, these products could be hydrolyzed in one pot to furnish the corresponding alkenyl-substituted cyclopropenones.
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Wang et al. (2026) studied this question.
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