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March 18, 2026International Journal of Laboratory Hematology

AML , Myelodysplasia‐Related With B/Myeloid MPAL Immunophenotype, Normal Karyotype, and SRSF2 / ASXL1 / FLT3 Co‐Mutations

Zhaodong Xu Monika Hudoba

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Key Points

This research aims to explore the relationship between specific genetic mutations and their immunophenotype in myelodysplasia-related MPAL.
Analysis of myelodysplasia-related MPAL cases with normal karyotype.
Characterization of immunophenotypes associated with co-mutations.
Investigation of genetic mutations including SRSF2, ASXL1, and FLT3.
Identified distinct immunophenotypes linked with SRSF2/ASXL1/FLT3 co-mutations.
Confirmed a normal karyotype in observed myelodysplasia-related MPAL cases.
Revealed implications for diagnosis and potentially treatment strategies.

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Implication

Observational study analyzes immunophenotype and genetic mutations in hematologic malignancies, suggesting potential diagnostic implications.

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Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69be38006e48c4981c67815e https://doi.org/10.1111/ijlh.70092

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Comparison of the clinicopathological features in myeloproliferative or myelodysplastic neoplasms with <i>SF3B1</i> / <i>JAK2</i> , <i>SF3B1</i> / <i>CALR</i> , or <i>SF3B1</i> / <i>MPL</i> co-mutations2025
2De novo acute myeloid leukemia harboring concurrent <scp> <i>CBFA2T3</i> </scp> :: <scp> <i>GLIS2</i> </scp> and <scp> <i>BCR</i> </scp> :: <scp> <i>ABL1</i> </scp> fusions in a non‐down syndrome adultOriginal Research · 2026
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4Mixed phenotype acute leukemia contains heterogeneous genetic mutations by next-generation sequencingOriginal Research · 2018 · 37 citations
5Resolving diagnostic uncertainty in rare <scp> <i>MPL</i> </scp> and <scp>CALR</scp> variants: A practical framework for the haematology clinicOriginal Research · 2026

More related papers

Additional myelodysplasia-related gene mutations alter clinical presentation and worsen prognosis in patients with <i>SRSF</i> / <i>TET2</i> co-mutated myeloid neoplasms2026
A Case of Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR) with Immunophenotypic Features Suggestive of B/Myeloid Mixed-Phenotype Acute Leukemia (MPAL), Harboring Multiple KMT2A Gene Amplifications2026
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