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April 2, 2026Cytometry Part B Clinical Cytometry

De novo acute myeloid leukemia harboring concurrent CBFA2T3 :: GLIS2 and BCR :: ABL1 fusions in a non‐down syndrome adult

Ting Li Xinyu Zhao Chang Zhang Ping Wu Man Chen Aixian Wang Hui Wang

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Key Points

To describe a unique case of acute myeloid leukemia featuring several concurrent gene fusions.
Case report detailing genetic findings in a single patient.
Analysis of fusion genes related to leukemia.
Comparison with existing literature on gene fusions in AML.
Identified concurrent fusions CBFA2T3, GLIS2, and BCR::ABL1 in the patient.
These fusions may influence the disease’s clinical characteristics and treatment response.

Implication

Case report uncovers acute myeloid leukemia with multiple gene fusions in an adult, highlighting unique genetic profiles.

Abstract

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69d1fc4fa79560c99a0a1e61 https://doi.org/10.1002/cyto.b.70029

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Concomitant Clonal CBFB::MYH11 and PDGFRB Fusions in a Case of De Novo Acute Myeloid LeukemiaOriginal Research · 2026 · 1 citations
2Acute Myeloid Leukemia with BCR::ABL1+ Fusion: A report of Two Cases and Review of Literature2025
3Concurrent <i>BCR‐ABL1</i> and core binding factor beta rearrangement in de novo acute myeloid leukemia: A case report and review of literature2024 · 3 citations
4A rare presentation of <scp>BCR‐ABL1</scp> and <scp>RUNX1‐MECOM</scp> rearrangement in a pediatric patient with acute myeloid leukemia2024 · 5 citations
5Advances in CBFA2T3::GLIS2 fusion gene in pediatric acute myeloid leukemia: from molecular mechanisms to targeted therapeutic strategiesReview · 2026

More related papers

Identification of an Elusive <i>CBFA2T3::GLIS2</i> Fusion Variant in Acute Megakaryoblastic Leukemia by Whole Genome Sequencing2026
Long-term remission of CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia with myeloid sarcoma following unrelated cord blood transplantation2025
<scp>AML</scp> , Myelodysplasia‐Related With B/Myeloid <scp>MPAL</scp> Immunophenotype, Normal Karyotype, and <scp>SRSF2</scp> / <scp>ASXL1</scp> / <scp>FLT3</scp> Co‐Mutations2026

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