Long-term remission of CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia with myeloid sarcoma following unrelated cord blood transplantation

Xuemei Guo; Xuan Wang; Yongren Wang; Liucheng Rong; Yongjun Fang; Rufeng Lin

doi:10.1080/10428194.2025.2584684

November 13, 2025Leukemia & lymphoma/Leukemia and lymphoma

Long-term remission of CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia with myeloid sarcoma following unrelated cord blood transplantation

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Key Points

Evaluate the clinical feasibility and therapeutic outcome of unrelated cord blood transplantation for high-risk pediatric acute megakaryoblastic leukemia harboring the CBFA2T3::GLIS2 fusion gene.
Assessed a pediatric patient diagnosed with CBFA2T3::GLIS2-positive acute megakaryoblastic leukemia presenting with an extramedullary myeloid sarcoma.
Administered allogeneic hematopoietic cell transplantation utilizing an unrelated umbilical cord blood graft after conditioning therapy.
Conferred durable, long-term disease remission despite the typically aggressive and refractory clinical course of CBFA2T3::GLIS2-positive leukemia.
Successfully cleared both systemic leukemia and extramedullary myeloid sarcoma without early disease recurrence.

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Implication

Clinical report demonstrates long-term remission in pediatric CBFA2T3::GLIS2 AML following unrelated cord blood transplantation, highlighting an effective strategy for high-risk disease.

Abstract

Infant acute megakaryoblastic leukemia (AMKL) carrying the CBFA2T3::GLIS2 fusion gene is a distinctive leukemia subtype that has an exceptionally poor outcome, with high-risk disease features and i...

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Guo et al. (2025) studied this question.

synapsesocial.com/papers/6ab9df3e0c63387e391d11f4 https://doi.org/10.1080/10428194.2025.2584684

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Long-term remission of CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia with myeloid sarcoma following unrelated cord blood transplantation

Key Points

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Implication

Abstract

Discussion

Cite This Study

Long-term remission of CBFA2T3::GLIS2-positive pediatric acute myeloid leukemia with myeloid sarcoma following unrelated cord blood transplantation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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