What question did this study set out to answer?

To describe a rare clinical presentation of pediatric acute megakaryoblastic leukemia characterized by the RAM immunophenotype and a CBFA2T3::GLIS2 gene fusion.

August 20, 2026Asian Journal of OncologyOpen Access

Infant with RAM acute megakaryoblastic leukemia (AMKL) immunophenotype and CBFA2T3::GLIS2 fusion: A case report

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To describe a rare clinical presentation of pediatric acute megakaryoblastic leukemia characterized by the RAM immunophenotype and a CBFA2T3::GLIS2 gene fusion.
Clinical and diagnostic case evaluation of an infant presenting with acute megakaryoblastic leukemia (AMKL).
Immunophenotypic profiling and genetic analysis to detect disease-defining chromosomal rearrangements and mutations.
Identified a rare RAM immunophenotypic profile accompanied by the disease-defining CBFA2T3::GLIS2 gene fusion.
Characterized the aggressive clinical course typically linked to this specific pediatric leukemia fusion and immunophenotype.

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Implication

Case report describes rare RAM acute megakaryoblastic leukemia with CBFA2T3::GLIS2 fusion in an infant, highlighting poor clinical prognosis and unique pediatric genetic profiles.

Cite This Study

Mehrotra et al. (2026) studied this question.

synapsesocial.com/papers/6a86b5b08a91293e6a1cd303 https://doi.org/10.25259/asjo_39_2025

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Implication

Case report describes rare RAM acute megakaryoblastic leukemia with CBFA2T3::GLIS2 fusion in an infant, highlighting poor clinical prognosis and unique pediatric genetic profiles.

Infant with RAM acute megakaryoblastic leukemia (AMKL) immunophenotype and CBFA2T3::GLIS2 fusion: A case report

Key Points

Discussion

Implication

Cite This Study

Infant with RAM acute megakaryoblastic leukemia (AMKL) immunophenotype and CBFA2T3::GLIS2 fusion: A case report

Key Points

Discussion

Implication

Cite This Study

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