Silver(I)‐2,4‐Diaminopyrimidine‐5‐Carbonitrile Based Aggregation‐Induced Emissive Metallogel for Selective Fluorescence Detection of Dopamine and Dinitrophenol

The development of fluorescent probes for the selective detection of biologically and environmentally relevant analytes has attracted considerable attention over the past two decades. This interest stems from their high selectivity and sensitivity, rapid response times, visual output, accurate quantification, and simplified sample preparation. Despite these advantages, the application of supramolecular gels for fluorescence‐based sensing of dopamine and nitroaromatic explosives in aqueous media remains relatively underexplored. In this study, 2,4‐diaminopyrimidine‐5‐carbonitrile (DPC) was synthesized, and its gelation behavior in the presence of silver ions was systematically investigated. The resulting metallogel (DPC) was subsequently employed as a fluorescent sensor for the detection of dopamine (DA) and nitroaromatic explosives {Dinitrophenol (DNP)}. Notably, DPC exhibited Aggregation‐Induced Emission (AIE) in a variety of solvents. In aqueous media, DPC demonstrated selective detection of DA and DNP through a fluorescence “turn‐off” response, which was attributed to fluorescence quenching via the inner filter effect (IFE).The sensing mechanism was thoroughly examined, and the detection limit was determined to be as low as 8 µM. Furthermore, the DPC‐based fluorescent probe exhibited excellent selectivity and sensitivity for quantifying DNP in soil samples and DA in urine through fluorescence quenching. High recovery rates confirmed the reliability of this probe for both environmental and biological sample analysis. This work underscores the potential of DPC‐based metallogels as effective fluorescent sensors, offering promising applications in clinical diagnostics and environmental monitoring.