Vertical numbering-up microfluidic architecture for scalable and homogeneous lipid nanoparticle production

Key Points

• This research aims to address the challenges in the industrial-scale production of lipid nanoparticles using microfluidic technology.
• Developed a vertical numbering-up microfluidic system
• Compared production quality and scalability with conventional methods
• Evaluated lipid nanoparticle size and uniformity
• Achieved higher production rates of lipid nanoparticles
• Demonstrated improved uniformity in size compared to traditional methods
• Provided insights into scalable manufacturing for nucleic acid delivery