This research demonstrates a biocatalytic approach to develop effective atorvastatin derivatives, highlighting its implications for drug development.
Tyrosinase hydroxylates 4-hydroxy atorvastatin to produce 3,4-dihydroxy atorvastatin, a potent HMG-CoA reductase inhibitor. The sequential P450–tyrosinase biotransformation of atorvastatin provides a cost-effective and sustainable route for producing active statin metabolites...
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Jeong et al. (2025) studied this question.
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