Observational study evaluates statistical methods for patient reported outcomes, suggesting improved analysis potential.
Relative to paired difference tests, multivariable regression approaches can better handle missing data, control for confounding factors, and provide information on the timing and magnitude of PRO changes. Regression methods therefore facilitate more informative conclusions in observational PRO analyses, and thus provide more detailed evaluations of treatment regimens from the patient's perspective.
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Williams et al. (2026) studied this question.
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