Patient-reported outcome (PRO) measures provide an important perspective on how patients feel and function that cannot be adequately captured by clinical measures. A PRO is any report that comes directly from a patient about a health condition or its treatment without interpretation of the patient's response by a clinician or anyone else. Clinical Pharmacology & Therapeutics (2008); 84, 2, 281–283 doi:10.1038/clpt.2008.128
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Burke et al. (2008) studied this question.