This review explores Dooshi Visha's role in allergic skin diseases, suggesting connections to modern immunology.
Background: Dooshi Visha, described in Ayurvedic classics as cumulative low-potency toxins from Viruddha Ahara, Agnimandya, and environmental factors, correlates with chronic allergic skin disorders like urticaria and eczema by disrupting Rakta Dhatu and immunity. Objective: This review examines the conceptual framework of Dooshi Visha and its pathogenesis in relation to allergic skin manifestations, integrating Ayurvedic and modern immunological perspectives. Methods: Comprehensive analysis of classical texts (Charaka, Sushruta) and contemporary literature on Dooshi Visha's role in hypersensitivity reactions, including Nija/Bahya Gara Visha effects on Twak Vikara. Results: Dooshi Visha induces Kapha-Pitta vitiation, Ojas kshaya, and IgE-mediated inflammation, manifesting as edema, pruritus, and dermatitis; parallels modern allergen-induced mast cell degranulation. Conclusion: Shodhana and Shamana therapies offer holistic detoxification, bridging Ayurveda with allergen avoidance strategies. Empirical validation is recommended for clinical application.
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Dr. Pooja Soni2* Dr. Krishna Jeevan Tiwari1 (2026) studied this question.
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