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The study aims to evaluate the cytotoxic effects of valproic acid on HeLa cells and assess changes in apoptotic gene expression.

Effect of valproic acid on expression of apoptotic markers in HeLa cell line – An in vitro study

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This in vitro study investigates valproic acid's cytotoxic effects on HeLa cells, indicating potential apoptotic activity.

The study aims to evaluate the cytotoxic effects of valproic acid on HeLa cells and assess changes in apoptotic gene expression.
HeLa cell line cultured in Dulbecco’s modified eagle medium
Treatment with varied concentrations of valproic acid (6.25–400 mM)
Cell viability assessed using MTT assay
mRNA expression analyzed via real-time PCR for p53, Bax, and Survivin
Significant reduction in HeLa cell viability observed with increasing VPA concentrations
Dose-dependent increase in p53 and Bax mRNA expression
Decrease in Survivin mRNA levels compared to untreated controls

Kar et al. (2026) studied this question.

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