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Demonstrates brain structure preservation in girls with central precocious puberty, suggesting hormonal influence.
After adjusting for age and intracranial volume, CPP showed preserved global and regional brain structure. Modest WM reduction and LH-related shifts in brain-CSF distribution suggest subtle hormonally mediated differences in maturational timing. This study provides the largest ICV-normalized volumetric MRI dataset in CPP.
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Özyılmaz et al. (2026) studied this question.
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