Multi-Color MPI via Field-Free Line Projections: A Linear Mixed Inverse Approach

Multi-color magnetic particle imaging (MPI) has been extensively studied for vascular intervention and tumor imaging, primarily via system matrix or relaxation-based methods. Field-free line (FFL) projection imaging avoids extensive calibrations of system matrices but encounters signal superposition in multi-color setups. We model this challenge as a linear mixed inverse problem, adapting a benchmark network from the blind source separation domain. This approach achieves effective separation on a vessel-aneurysm phantom, demonstrating promising applications.