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March 22, 2026Current Materials Science

Nanocrystalline Cellulose as a Dual-functional Excipient: A Sustainable Superdisintegrant and Binder for Oral Solid Dosage Forms

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Authors

SCShikha Baghel ChauhanMManishaCJChirag Jain

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Overview

This research demonstrates the effectiveness of biodegradable nanocrystalline cellulose in oral formulations, indicating its potential in precision medicine and sustainable drug delivery.

Key Points

  • To explore nanocrystalline cellulose as a dual-functional excipient for oral solid dosage forms.
  • Examined sources and extraction techniques of nanocrystalline cellulose.
  • Analyzed wet and dry granulation processes.
  • Investigated binding and disintegration mechanisms with natural polymers.
  • Nanocrystalline cellulose exhibited improved disintegration and binding compared to conventional excipients.
  • Demonstrated significant mechanical strength and swelling capacity.
  • Highlighted environmental sustainability and compatibility with active pharmaceutical ingredients.

Cite This Study

Chauhan et al. (2026) studied this question.

synapsesocial.com/papers/69bf390ac7b3c90b18b43437https://doi.org/10.2174/0126661454439894260123053104
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