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Reports unique mitoxyperilysis cell death, driven by fasting and immune agonists, suggesting therapeutic implications.
Recent work by Wang and colleagues reveals a unique mode of cell death called mitoxyperilysis, driven by mitochondrial proximity-dependent rupture of the plasma cell membrane. This lytic cell death is triggered by immune agonists combined with fasting or nutrient starvation, offering therapeutic implications in sepsis and cancer.
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Al-Zidan et al. (2026) studied this question.
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