Comparison of Clinical Profile and Outcomes Associated with Adenovirus and Non-adenovirus Viral Pneumonia in Children Admitted to a Pediatric Intensive Care Unit: A Single-center Retrospective Study
This retrospective study compares outcomes in children with adenovirus and non-adenovirus pneumonia, highlighting key clinical differences.
Key Points
The study aims to compare the clinical profiles and outcomes of viral pneumonia caused by adenovirus and non-adenovirus in children admitted to a PICU.
Retrospective review of case records of children with viral pneumonia diagnosed via PCR analysis.
Assessment of clinical profiles, laboratory parameters, and outcomes, including mortality and need for mechanical ventilation.
Utilized univariate and multivariate logistic regression analyses to identify risk factors for mortality and bronchiolitis obliterans.
Out of 148 children with severe pneumonia, 42.5% had viral isolates, with adenovirus (49.2%) being nearly equally prevalent as non-adenovirus viruses (50.7%).
AdV pneumonia patients were significantly younger, with 100% under 5 years, compared to 81.2% in the non-AdV group.
Leukopenia occurred more frequently in the AdV group (16.1% vs 0%).
Short-term outcomes, including mortality and length of stay, were similar, but incidence of bronchiolitis obliterans was higher in AdV cases (22.5% vs 3.1%).