Concurrent immunotherapy is associated with increased radiation necrosis risk in lung cancer patients with brain metastases treated with stereotactic radiosurgery
To evaluate the association between concurrent immunotherapy and radiation necrosis risk in lung cancer patients receiving stereotactic radiosurgery for brain metastases.
Analyzed lung cancer patients undergoing SRS for brain metastases
Included prior whole-brain radiotherapy and planning target volume size in evaluation
Concurrent immunotherapy was significantly correlated with increased radiation necrosis risk
Prior whole-brain radiotherapy and larger planning target volumes also contributed to this risk
Abstract
In patients with lung cancer undergoing SRS for brain metastases, factors including prior WBRT, a larger PTV, and concurrent immunotherapy were significantly associated with the development of RN.