What question did this study set out to answer?

The aim is to compare the diagnostic accuracy of IOTA-SR and RMI 1 in evaluating adnexal masses before surgery.

March 22, 2026Open Access

Diagnostic Accuracy of IOTA-SR vs RMI 1 in Evaluation of Women with Adnexal Masses: A Cross-sectional Study

Key Points

The aim is to compare the diagnostic accuracy of IOTA-SR and RMI 1 in evaluating adnexal masses before surgery.
Conducted a cross-sectional observational study over 18 months.
107 women with adnexal masses were evaluated using both RMI 1 and IOTA-SR.
Findings were compared with the gold standard of histopathological examination.
RMI 1 sensitivity was 32.79% and specificity was 89.13%.
IOTA-SR showed a higher sensitivity of 54.90% and 100% specificity.
IOTA-SR had a positive predictive value of 100%, while RMI 1 was 80%.
Overall diagnostic accuracy for IOTA-SR was 57.01%, compared to RMI 1.

Abstract

Background: Ovarian malignancy imposes a significant burden due to its high mortality rate and often late-stage diagnosis.Early detection techniques and better treatments are therefore essential for reducing this burden.For this reason, prior to surgery, it is critical to classify adnexal masses and distinguish between malignant and benign features in order to minimize anxiety among the patients and facilitate effective decisionmaking regarding the best course of treatment.The purpose of this was to assess and compare the diagnostic accuracy of the International ovarian tumor analysis simple rules (IOTA-SR) and risk of malignancy index 1 (RMI 1) with gold standard histopathological examination (HPE) in evaluation of adnexal masses.Materials and methods: Over the course of 18 months, cross-sectional observational research with diagnostic test evaluation was conducted at a tertiary care facility.Overall, 107 women participated in the present study based on the eligibility criteria and were evaluated by both RMI and IOTA. Results:The results demonstrated that the RMI 1 test's validity and reliability were evaluated against HPE findings, which are considered the gold standard.The test showed a sensitivity of 32.79% (22.33-45.28%),a specificity of 89.13% (76.96-95.27%),a negative predictive value (NPV) of 50% (39.42-60.58%),and a positive predictive value (PPV) of 80% (60.87-91.14%).Whereas, the IOTA-SR test's performance metrics demonstrated that the sensitivity was 54.90% (45.24-64.21),specificity was 100% (56.55-100), the NPV was 9.80% (4.261-20.98), the PPV was 100% (93.58-100), and the diagnostic accuracy was 57.01%(47.55-65.99).Conclusion: Overall, IOTA-SR has high specificity and PPV but moderate sensitivity and diagnostic accuracy, with low NPV and slight agreement with HPE findings.Hence, the study concluded that IOTA-SR outperformed RMI in differentiating ovarian masses preoperatively into malignant and benign.

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Cite This Study

Suryawanshi et al. (Fri,) studied this question.

synapsesocial.com/papers/69bf8692f665edcd009e8f16 https://doi.org/https://doi.org/10.5005/jp-journals-10006-2672

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