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Real-world outcomes show transdermal estradiol spray effectively alleviates symptoms in menopausal women, suggesting its practicality.
The E₂ spray improved HRQoL and was well tolerated. Flexible dosing, ease of use and real-world effectiveness support that the spray is a practical, user-friendly treatment for menopausal symptoms.
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Polo-Kantola et al. (2026) studied this question.
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