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March 19, 2026American Journal of Veterinary ResearchOpen Access

Intra-articular hydrogel therapeutics exhibit anti-inflammatory effects on cytokine-stimulated equine cartilage and synovial membrane explants

Erica J. Secor M. Steen Thomas Emma Chu Sarah Hazzard Sara Raimondi H. Reesink

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Key Points

Investigate the anti-inflammatory effects of intra-articular hydrogel therapeutics on equine cartilage and synovial membrane.
Evaluated the impact of CEHM, 2.5% iPAAG, and hyaluronic acid on cytokine-stimulated explants
Conducted assays to measure inflammatory markers in cartilage and synovial membrane tissues
CEHM and 2.5% iPAAG exhibited significant anti-inflammatory effects compared to controls
Hyaluronic acid showed similar effects, suggesting multiple therapeutic mechanisms beyond lubrication

Implication

Study demonstrates anti-inflammatory effects of hydrogel therapeutics in equine cartilage and synovial membrane, indicating potential broader healing roles.

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Cite This Study

Secor et al. (2026) studied this question.

synapsesocial.com/papers/69bf8692f665edcd009e8f67 https://doi.org/10.2460/ajvr.25.12.0454

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