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March 19, 2026Scandinavian Journal of Gastroenterology

Collagenous sprue across five decades (1970–2025): a systematic review

Thomas Stirrat Maximilien Andrew Wilkey Stella Kim Ade Waterman Mark Mattar

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Key Points

To analyze management strategies for collagenous sprue over five decades and their implications for patient outcomes.
Conducted a systematic review across literature published from 1970 to 2025.
Evaluated effectiveness of early recognition and medication withdrawal.
Assessed impact of nutritional support and steroid-based therapy on patient improvement.
Early recognition and treatment generally lead to improvement in symptoms.
Medication review and withdrawal are crucial for management success.
Despite management strategies, relapse and mortality rates remain high.

Implication

Systematic review uncovers management strategies for collagenous sprue, indicating high risks of relapse and mortality.

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Cite This Study

Stirrat et al. (2026) studied this question.

synapsesocial.com/papers/69bf86ecf665edcd009e9049 https://doi.org/10.1080/00365521.2026.2641509

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