Sustained clinical and histological remission of collagenous sprue with Anti–TNF-α therapy

C. De Angelis; K. Yaqubi; H. Störkmann; M. Seidl; I. Esposito; T. Luedde; P. May

doi:10.3205/26vzmnrw135

June 18, 2026Open Access

Sustained clinical and histological remission of collagenous sprue with Anti–TNF-α therapy

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Key Points

The study aims to evaluate the efficacy of anti-TNF-α therapy in achieving remission in patients with collagenous sprue.
Patients diagnosed with collagenous sprue were treated with anti-TNF-α therapy.
Clinical and histological assessments were conducted to determine remission status.
Patients showed significant clinical improvement with a decrease in chronic diarrhea.
Histological examination revealed normalization of the subepithelial collagen band and villous structure.

Implication

Shows sustained remission in collagenous sprue using anti-TNF-α therapy, suggesting effective treatment options.

Abstract

Background and objective: Collagenous sprue is a rare and severe small intestinal enteropathy characterized by a markedly thickened subepithelial collagen band, villous atrophy, crypt hyperplasia, and intraepithelial lymphocytosis. Clinically, patients present with chronic diarrhoea, malabsorption, [for full text, please go to the a.m. URL]

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Cite This Study

Angelis et al. (2026) studied this question.

synapsesocial.com/papers/6a36309edb0793dc1a537b3d https://doi.org/10.3205/26vzmnrw135

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Sustained clinical and histological remission of collagenous sprue with Anti–TNF-α therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Sustained clinical and histological remission of collagenous sprue with Anti–TNF-α therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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