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March 22, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

An APE1 Redox Inhibitor Attenuates Pathological Retinal Vascularization by Suppressing FGF2 Angiogenic Signaling

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CYChenfei YanQFQiang FuJWJiwen Wang

Key Points

  • The research aims to evaluate the effects of APE1 redox inhibitor Refi-10 on retinal vascularization and FGF2 signaling.
  • Assessment of APE1 and FGF2 signaling pathways
  • Evaluation of Refi-10 effects on retinal vascularization
  • Comparison of Refi-10 with VEGF inhibition
  • Refi-10 significantly attenuates pathological retinal vascularization
  • Suppression of FGF2 signaling correlates with reduced vascularization
  • Findings support APE1 and FGF2 as therapeutic targets for vascular retinopathies

Abstract

These findings nominate APE1 and FGF2 signaling as promising therapeutic targets, and show that Refi-10 holds potential as a drug candidate for vascular retinopathies, offering an alternative or complementary approach to VEGF inhibition.

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Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/69bf86ecf665edcd009e9053https://doi.org/10.1167/iovs.67.3.47
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