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This research investigates how variants of the FTO gene are linked to obesity and overweight in adults.

March 22, 2026BMC Endocrine DisordersOpen Access

Impact of fat mass and obesity-associated (FTO) gene variants on adult obesity and overweight: a comprehensive meta-analysis

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Meta-analysis reveals strong associations between FTO gene variants and obesity risk in adults, suggesting tailored prevention strategies.

This research investigates how variants of the FTO gene are linked to obesity and overweight in adults.
Conducted a comprehensive literature search across PubMed, Scopus, and Web of Science.
Performed meta-analysis on data from 41 studies with over 34,000 participants.
Analyzed FTO polymorphisms across various geographic regions and demographics.
Identified significant associations between FTO variants and obesity, particularly rs1421085 and rs9939609.
Noted the strongest effect for rs1421085 with an odds ratio of 2.16 for obesity.
Found geographical variations in the impact of different FTO variants on obesity prevalence.

Eghbali et al. (2026) studied this question.

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Meta-analysis reveals strong associations between FTO gene variants and obesity risk in adults, suggesting tailored prevention strategies.