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March 22, 2026PEDIATRICS

Folic Acid for the Prevention of Neural Tube Defects

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Overview

Prospective randomized study shows folic acid prevents NTD recurrence in high-risk pregnancies, suggesting an effective preventive measure.

Key Points

  • To evaluate the effectiveness of folic acid supplementation in preventing neural tube defects (NTDs) in high-risk pregnancies.
  • Conducted a well-designed prospective randomized study.
  • Included high-risk patients with a history of NTDs.
  • Administered daily doses of 4 mg of folic acid before and during early pregnancy.
  • Demonstrated a 71% reduction in the recurrence of NTDs.
  • Included participants from multiple countries.
  • Confirmed the effectiveness of folic acid in preventing NTDs.

Cite This Study

A 1993 study studied this question.

synapsesocial.com/papers/69bf899af665edcd009e95c9https://doi.org/10.1542/peds.92.3.493
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