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October 8, 2025International Journal of Health Sciences

The Effect of a Folic Acid Supplementation Program During the Preconception Period on Reducing the Risk of Neural Tube Defects in Pregnancy

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Authors

AHAstin Nur HanifahNNNurhaedah Nurhaedah

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Overview

Prospective cohort study finds folic acid supplementation lowers neural tube defects risk in women, suggesting routine use before pregnancy.

Key Points

  • Folic acid supplementation reduced the incidence of neural tube defects significantly during the preconception period.
  • The intervention group showed an NTD incidence of 0.83%, compared to 6.67% in the control group, indicating effectiveness.
  • Using a prospective cohort design, 240 women were assessed for the impact of preconception folic acid supplementation.
  • This evidence supports routine supplementation for women planning pregnancy to reduce NTD risk effectively.

Cite This Study

Hanifah et al. (2025) studied this question.

synapsesocial.com/papers/68e6860af44b9035634c211chttps://doi.org/10.59585/ijhs.v3i3.790
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Folic Acid for the Prevention of Neural Tube Defects1993
  2. 2Folic Acid Supplementation to Prevent Neural Tube Defects Updated Evidence Report and Systematic Review for the US Preventive Services Task Force2024 · 6 citations
  3. 3Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age2026 · 2 citations
  4. 4FREQUENCY OF NEURAL TUBE DEFECT(NTD) AND ASSOCIATED ANOMALIES IN WOMEN WITH PERINATAL FOLIC ACID SUPPLEMENTATION PRESENTING TO HAYATABAD MEDICAL COMPLEX, PESHAWAR2025
  5. 5Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age2025