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February 19, 2026NutrientsOpen Access

Best Evidence Summary of Folic Acid Supplementation for Prevention of Neural Tube Defects in Women of Childbearing Age

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Authors

JLJiahe LiBCBihui ChenNLNing Liu

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Overview

Systematic review provides evidence for folic acid's role in preventing neural tube defects in women, suggesting clear guidelines for practitioners.

Key Points

  • To summarize best evidence on folic acid supplementation for preventing neural tube defects in women of childbearing age.
  • Systematic search of 7 databases and 20 professional websites from 2013 to 2025
  • Targeted clinical guidelines, expert consensuses, and best practices
  • Quality assessment and synthesis of retrieved literature into thematic dimensions.
  • 14 evidence statements organized into five thematic dimensions related to NTDs and folic acid
  • Recommendations include initiation of supplementation at least 3 months preconception
  • Daily doses suggested: 0.4 mg for low-risk, 1.0 mg for moderate-risk, and 4.0–5.0 mg for high-risk women.
  • Dietary intake alone is insufficient, and routine testing for folate is discouraged.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6996a788ecb39a600b3ed4b7https://doi.org/10.3390/nu18040641
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