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This analysis explores the incidence and survival outcomes of double primary cancers, aiming to inform screening protocols in Taiwan.

Unveiling the Characteristics and Survival Outcomes of Double Primary Cancers in Taiwan: A Nationwide Population‐based Comparison Cohort Study

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This analysis explores the incidence and survival outcomes of double primary cancers, aiming to inform screening protocols in Taiwan.
Conducted a retrospective cohort analysis using Taiwan Cancer Registry and patient databases from 2000 to 2017.
Identified double primary cancers based on International Classification of Diseases for Oncology codes.
Compared cancer site distributions, stage distributions, relative risks, and survival rates among three cohorts: single primary, synchronous, and metachronous cancers.
4.17% of patients with initial cancer diagnoses developed second cancers.
Men with oral cancer frequently developed esophageal cancer, while women commonly showed breast, colorectal, or lung cancer as double cancers.
Synchronous cancers were often diagnosed at advanced stage IV, with significant mortality rates higher than single primary cancers.

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A nationwide cohort analysis reveals survival disparities among double primary cancer types in Taiwan, suggesting urgent screening needs.

Lin et al. (2026) studied this question.

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