What question did this study set out to answer?

To summarize the molecular pathways and bidirectional cross-talk connecting inflammation and coagulation in the pathogenesis of sepsis.

February 1, 2010Critical Care Medicine

Inflammation and coagulation

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To summarize the molecular pathways and bidirectional cross-talk connecting inflammation and coagulation in the pathogenesis of sepsis.
Narrative synthesis of molecular pathways mediating inflammation-induced coagulation activation and coagulation-driven inflammatory signaling.
Evaluation of pro-inflammatory cytokines, tissue factor expression, endothelial anticoagulant mechanisms, and protease-activated cellular pathways.
Pro-inflammatory cytokines trigger coagulation by inducing tissue factor expression while simultaneously down-regulating physiological anticoagulant mechanisms and impairing fibrinolysis.
Thrombin generation and activated coagulation proteases engage specific receptors on endothelial and inflammatory cells to amplify the systemic inflammatory cascade.

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Implication

Mechanistic review reveals extensive cross-talk between inflammatory mediators and coagulation pathways in sepsis, highlighting interdependent cascades that exacerbate systemic disease.

Cite This Study

Levi et al. (2010) studied this question.

synapsesocial.com/papers/69c0254a7079ede9cb9575fa https://doi.org/10.1097/ccm.0b013e3181c98d21

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Implication

Mechanistic review reveals extensive cross-talk between inflammatory mediators and coagulation pathways in sepsis, highlighting interdependent cascades that exacerbate systemic disease.

Inflammation and coagulation

Key Points

Discussion

Implication

Cite This Study

Inflammation and coagulation

Key Points

Discussion

Implication

Cite This Study

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