Does the apo B:apo A-I ratio improve prediction of Coronary Heart Disease compared to total cholesterol:HDL-C in men and women?
Apo B and apo A-I measurements do not provide incremental utility over standard total cholesterol and HDL-C for CHD prediction in clinical practice.
In this large, population-based cohort, the overall performance of apo B:apo A-I ratio for prediction of CHD was comparable with that of traditional lipid ratios but did not offer incremental utility over total cholesterol:HDL-C. These data do not support measurement of apo B or apo A-I in clinical practice when total cholesterol and HDL-C measurements are available.
Ingelsson et al. (Tue,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: