What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

To evaluate the impact of combined CogSMART and BrainHQ interventions on cognitive performance in people living with HIV in low-income settings.

March 23, 2026BMC NeurologyOpen Access

Changes in cognitive performance following combined CogSMART-SA and BrainHQ interventions: a pilot study

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Authors

HGHetta GouseUniversity of Cape Town ZNZanele Precious Nhlabatsi-KhumaloUniversity of Cape Town RCRhiannon ChernotskyUniversity of Cape Town

Discussion

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Implication

Pilot study shows reduced neurocognitive impairment in low-income countries among PLWH undergoing cognitive remediation therapy, suggesting effective intervention strategies.

Key Points

To evaluate the impact of combined CogSMART and BrainHQ interventions on cognitive performance in people living with HIV in low-income settings.
Pilot study design with random assignment to intervention and control groups
Participants underwent 10 CogSMART and 20 BrainHQ sessions over 5 weeks
Neuropsychological test battery and self-report measures administered at baseline and exit
30% of intervention participants met criteria for neurocognitive impairment at study exit compared to 70% at baseline
Significant time x group interaction effects were detected for Global Deficit Score (p < 0.001) and delayed verbal memory (p = 0.050)
Intervention participants showed greater cognitive gains than controls over the trial period

Cite This Study

Gouse et al. (2026) studied this question.

synapsesocial.com/papers/69c08bcaa48f6b84677f993d https://doi.org/10.1186/s12883-026-04778-9

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Implication

Pilot study shows reduced neurocognitive impairment in low-income countries among PLWH undergoing cognitive remediation therapy, suggesting effective intervention strategies.

Changes in cognitive performance following combined CogSMART-SA and BrainHQ interventions: a pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

Changes in cognitive performance following combined CogSMART-SA and BrainHQ interventions: a pilot study

Discussion

Member takes

Implication

Key Points

Cite This Study

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