What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

To synthesize evidence on the progression of cardiometabolic outcomes in first-episode psychosis over time.

March 23, 2026Schizophrenia BulletinOpen Access

Short-, Medium-, and Long-Term Cardiometabolic Outcomes in First-Episode Psychosis: A Systematic Review and Meta-analysis

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To synthesize evidence on the progression of cardiometabolic outcomes in first-episode psychosis over time.
Systematic review and meta-analysis following PRISMA and MOOSE guidelines.
Search conducted on Medline, Embase, PsycInfo, and CINAHL+ up to July 2025.
Included studies of first-episode psychosis with ≤28 days of antipsychotic exposure at baseline.
Obesity prevalence increased from 5.4% at baseline to 26.6% at 1-3 years.
Metabolic syndrome prevalence rose from 8.5% at baseline to 18.2% at 1-3 years.
Type 2 diabetes prevalence increased from 0.5% to 5.0% by >5 years.
Weight increased by +2.5 kg at 4-8 weeks and +13.4 kg at >5 years.

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Implication

Systematic review and meta-analysis revealed increased cardiometabolic risk in first-episode psychosis, highlighting the need for early monitoring and intervention.

Cite This Study

Zierotin et al. (2026) studied this question.

synapsesocial.com/papers/69c08bcaa48f6b84677f9999 https://doi.org/10.1093/schbul/sbag008

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Implication

Systematic review and meta-analysis revealed increased cardiometabolic risk in first-episode psychosis, highlighting the need for early monitoring and intervention.

Short-, Medium-, and Long-Term Cardiometabolic Outcomes in First-Episode Psychosis: A Systematic Review and Meta-analysis

Key Points

Discussion

Implication

Cite This Study

Short-, Medium-, and Long-Term Cardiometabolic Outcomes in First-Episode Psychosis: A Systematic Review and Meta-analysis

Key Points

Discussion

Implication

Cite This Study

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