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March 1, 2026JHLT OpenOpen Access

Dual-energy CT based scoring to estimate perfusion changes after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension

Jacob Valentin Hansen Mads Dam Lyhne Mette Wørmer Poulsen Lina Karout Gratien Andersen Jens Erik Nielsen-Kudsk Mannudeep K. Kalra Asger Andersen

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Key Points

This research aims to evaluate the efficacy of dual-energy CT in assessing changes in lung perfusion after balloon pulmonary angioplasty in CTEPH patients.
Conducted a prospective study with 17 CTEPH patients undergoing BPA.
Utilized dual-energy CT pulmonary angiography to assess lung perfusion before, and after BPA treatments.
Two observers graded perfusion defects on PBV images and calculated perfusion defect scores.
Perfusion defect score significantly improved from baseline (114.7) to second scan (8.13.4, p<0.001) and follow-up (7.43.6, p<0.0001).
Pulmonary vascular resistance decreased from baseline (8.48) to follow-up (5.09, p<0.001).
Intra-observer agreement was substantial, while inter-observer agreement was variable, yet improved when evaluating PD score changes.

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Implication

Prospective study evaluates lung perfusion alterations in CTEPH patients post-BPA using dual-energy CT, suggesting its diagnostic importance.

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Cite This Study

Hansen et al. (2026) studied this question.

synapsesocial.com/papers/69c0de74fddb9876e79c12d7 https://doi.org/10.1016/j.jhlto.2026.100543

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Development of a lung perfusion automated quantitative model based on dual-energy CT pulmonary angiography in patients with chronic pulmonary thromboembolism2025 · 5 citations
2Evaluation of balloon pulmonary angioplasty using lung perfusion SPECT in patients with chronic thromboembolic pulmonary hypertensionOriginal Research · 2022 · 13 citations
3Imaging characteristics relevant to pulmonary perfusion improvement after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertensioncohort · 2023
4Appropriate Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension Improves Right Ventricular Ejection Fraction via Lung Perfusion Scancase_series · 2022 · 2 citations
5Comparative assessment of qualitative and quantitative perfusion with dual-energy CT and planar and SPECT-CT V/Q scanning in patients with chronic thromboembolic pulmonary hypertensionOriginal Research · 2018 · 46 citations

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A28-11 The Impact of Increased Lung Volume After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension2026

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