What question did this study set out to answer?

This research aims to assess the accuracy of quantifying phenolic compounds using different liquid chromatography methods.

March 23, 2026Journal of Chromatography AOpen Access

Assessment of the Inaccuracy Associated with the Quantification of Phenolic Compounds using UHPLC-DAD and HPLC-MS/MS

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This research aims to assess the accuracy of quantifying phenolic compounds using different liquid chromatography methods.
Conducted quantitative analysis of phenolic equivalents using HPLC-MS and UHPLC-DAD.
Performed external standard calibration for 6 phenolic acids and 8 flavonoids.
Compared the accuracy of quantification in terms of molarity and equivalent standards among the methods utilized.
UHPLC-DAD exhibited lower inaccuracy in quantifying flavonoids compared to HPLC-MS/MS.
No significant differences were found with specific flavonoids when quantifying eriocitrin solution.
HPLC-MS/MS showed varying concentration values across standards, indicating a greater error.

Authors

RZRosa ZapataUniversidad Politécnica de Cartagena FAFrancisco Artés-HernándezUniversidad Politécnica de Cartagena

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Implication

Quantitative analysis reveals accuracy disparities in phenolic compound measurement using different chromatographic methods, suggesting improved standards are necessary.

Cite This Study

Zapata et al. (2026) studied this question.

synapsesocial.com/papers/69c0df0bfddb9876e79c1517 https://doi.org/10.1016/j.chroma.2026.466918

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Implication

Quantitative analysis reveals accuracy disparities in phenolic compound measurement using different chromatographic methods, suggesting improved standards are necessary.

Assessment of the Inaccuracy Associated with the Quantification of Phenolic Compounds using UHPLC-DAD and HPLC-MS/MS

Key Points

Discussion

Implication

Cite This Study

Assessment of the Inaccuracy Associated with the Quantification of Phenolic Compounds using UHPLC-DAD and HPLC-MS/MS

Key Points

Discussion

Implication

Cite This Study

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