Identification of a Small Molecule CAPON Binder Using Affinity Selection-Mass Spectrometry Screening

Key Points

• The aim is to identify small molecule binders for CAPON (NOS1AP) through screening methods.
• Conducted affinity selection-mass spectrometry screening
• Evaluated binding affinity of small molecules
• Identified MA32 as a binder to CAPON
• MA32 binds to CAPON with a dissociation constant (Kd) of a specified value
• First small molecule binder identified for CAPON