What question did this study set out to answer?

To develop a rapid and accurate detection method for imazalil using nanobodies in food and environmental samples.

March 23, 2026Biomedical AnalysisOpen Access

Development of nanogold immunochromatographic assay strip based on novel nanobody for rapid detection of imazalil in food and environmental water samples

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Novel nanobody-based assay detects imazalil in food and water samples, suggesting reliable monitoring methods.

To develop a rapid and accurate detection method for imazalil using nanobodies in food and environmental samples.
Developed a novel anti-IMZ nanobody from alpaca phage display library
Used a nanogold immunochromatographic assay (Nb-GICA) for IMZ detection
Simulated molecular recognition mechanism and explored optimization strategies for antibody sensitivity
Tested assay performance on fruits and environmental water samples.
Achieved rapid detection time of 8 minutes per test
Demonstrated a broad linear range (8.87–380.57 ng/mL)
Achieved a limit of detection (LOD) of 6.05–16.56 ng/mL
Displayed average recovery rates ranging from 82.6% to 117.5% in tested samples, corroborating GC-MS/MS results.

Zhang et al. (2026) studied this question.

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