Objectives We investigated the associations of nutrition impact symptoms (NISs) with sleep disturbance among advanced cancer patients receiving palliative care. Methods A secondary analysis of a self-administered survey was performed. Participants evaluated 3 components of sleep disturbance (ie, difficulty falling asleep, difficulty staying asleep, and early awakening) and 19 NISs using numerical rating scales (0-10). They also used several screening tools, including the Hospital Anxiety and Depression Scale (HADS). Finally, 2 groups were analyzed by multivariate logistic regression analysis using a cutoff score of 4 for each of the 3 components (< 4, lower score group; ≥ 4, higher score group). Results Ultimately, 184 patients were included. For all 3 components, higher score groups had significantly greater numbers of NISs with a score ≥ 4 and higher anxiety and depression than lower score groups. In the logistic regression model using HADS-Anxiety for difficulty falling asleep, significantly higher adjusted odds ratios (ORs) were observed in the 4-6 NISs (with a score ≥ 4) group than in the no NISs (with a score ≥ 4) group (7.15 95% confidence interval (CI), 1.24-41.06). Using HADS-Depression for difficulty falling asleep and difficulty staying asleep, significantly higher adjusted ORs were observed in the 4-6 NISs group than in the no NISs group (7.43 95% CI, 1.29-42.74; 4.47 95% CI, 1.02-19.69, respectively). Conclusions Having 4 or more NISs with a score ≥ 4 was significantly associated with sleep disturbance. Cachexia-related symptom management is essential to improve patients’ sleep status.
Amano et al. (Sat,) studied this question.
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