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March 24, 2026European Urology Oncology2 citationsOpen Access

Monogenic and Polygenic Risk for Kidney Cancer in Two Large Biobanks

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JWJun WeiCenter for Genomic ScienceAMAshley MulfordGenomic Health (United States)ZSZhuqing ShiCenter for Genomic Science

Key Points

  • The aim is to evaluate the role of both monogenic and polygenic risk factors in kidney cancer.
  • Analyzed data from two large biobanks
  • Assessed common genetic factors using polygenic risk scores (PRS)
  • Combined analysis of rare mutations and common risk factors
  • Identified high-risk individuals through common genetic factors
  • Combined risk assessment improved accuracy in identifying kidney cancer risk
  • Suggests earlier screening and prevention strategies for kidney cancer

Abstract

Many patients with kidney cancer do not carry rare inherited mutations. Our study shows that common genetic factors, captured in a PRS, can also identify high-risk individuals. Combining both rare mutations and common polygenic risks provides a more complete assessment of kidney cancer risk and may aid in earlier screening and prevention.

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Cite This Study

Wei et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d3833https://doi.org/10.1016/j.euo.2026.03.004
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