Highlights how ESM1 influences angiogenesis and drug resistance in hepatocellular carcinoma, suggesting new therapy targets.
The ESM1-ANGPTL4-FASN-trioleate axis orchestrates metabolic reprogramming and endothelial activation, representing a promising therapeutic target. Future studies should explore combination therapies targeting this axis and overcoming bevacizumab resistance in HCC.
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Chen et al. (2026) studied this question.
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