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March 24, 2026CureusOpen Access

Denture-Related Irritation Fibroma With Myxoid Change of the Anterior Hard Palate: A Clinicopathologic Case Report

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Case report illustrates a rare denture-related lesion with myxoid change, indicating the importance of proper denture care.

This report aims to describe a rare case of denture-related irritation fibroma with myxoid change and moderate epithelial dysplasia.
Presented a clinical case of a 54-year-old man with a mass on the anterior hard palate.
Performed an incisional biopsy followed by excision with a safety margin and subperiosteal dissection.
Conducted histopathological examination and Alcian blue staining for definitive diagnosis.
The lesion displayed moderate epithelial dysplasia and myxoid matrix beneath stratified squamous epithelium.
Histopathology confirmed a fibrous nodule with hyperkeratosis and acanthosis.
Postoperative healing was smooth, and no recurrence was noted after interventions.

Sato et al. (2026) studied this question.

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