What question did this study set out to answer?

To identify prognostic factors and molecular characteristics in patients with lung cancer associated with interstitial lung disease (LC-ILD).

March 24, 2026Lung CancerOpen Access

Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

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To identify prognostic factors and molecular characteristics in patients with lung cancer associated with interstitial lung disease (LC-ILD).
Conducted a retrospective cohort study on LC-ILD patients at Marseille University Hospital
Analyzed patient data from multidisciplinary team discussions
Performed molecular profiling on available patient samples
A total of 102 LC-ILD patients were included, with a mean age of 68.8 years and 83% male
Molecular profiling revealed TP53, KRAS, and PI3KCA alterations
ARE occurred in 42% of patients and were fatal in 67%
Median overall survival was noted at 17.7 months
Higher KCO and good performance status were linked to improved survival

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Implication

Retrospective cohort study identifies prognostic factors and molecular landscape in lung cancer with interstitial lung disease, suggesting urgent therapeutic needs.

Cite This Study

Goga et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d3923 https://doi.org/10.1016/j.lungcan.2026.109379

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Implication

Retrospective cohort study identifies prognostic factors and molecular landscape in lung cancer with interstitial lung disease, suggesting urgent therapeutic needs.

Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

Key Points

Discussion

Implication

Cite This Study

Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

Key Points

Discussion

Implication

Cite This Study