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March 24, 2026Clinical and Translational Radiation OncologyOpen Access

Outcome and safety of SBRT in centrally and ultra-centrally located lung tumours: A PRISMA-based systematic review and Meta-Analysis

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Authors

SWShari WiegreffeSASonja AdebahrTST. Schimek-Jasch

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Overview

Meta-analysis reports safety and efficacy of SBRT in centrally and ultra-centrally located lung tumours, suggesting effective treatment options.

Key Points

  • Evaluate the safety and outcomes of SBRT in centrally and ultra-centrally located lung tumours.
  • Conducted a systematic review and meta-analysis following PRISMA guidelines.
  • Included 57 retrospective and 12 prospective trials.
  • Utilized Pubmed/MEDLINE for literature search and outcome parameter analysis.
  • Median overall survival was 28 months for ultra-central and 39.4 months for central lesions.
  • Pooled grade 3-5 toxicity was low for both tumor locations.
  • Most common severe complication was haemorrhage, with a low proportion in ultra-central (0.48%) compared to central tumours (0.12%).

Cite This Study

Wiegreffe et al. (2026) studied this question.

synapsesocial.com/papers/69c2294caeb5a845df0d3948https://doi.org/10.1016/j.ctro.2026.101151
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