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March 24, 2026Cureus0 citationsOpen Access

Preoperative Biomarkers Predicting Cholecystitis Severity

The Role of Preoperative Neutrophil-to-Lymphocyte Ratio and C-reactive Protein in Predicting the Severity of Cholelithiasis With Cholecystitis

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Authors

KKKanishk KSPShivanagouda S PatilRBRamakanth Baloorkar

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Overview

Prospective observational study evaluates preoperative NLR and CRP as predictors of cholecystitis severity, suggesting clinical utility.

Key Points

  • This study aims to assess the relationship between preoperative neutrophil-to-lymphocyte ratio and C-reactive protein levels with the severity of cholelithiasis and clinical outcomes.
  • Conducted as a prospective observational study over two years in a tertiary care center
  • Included 48 patients undergoing laparoscopic cholecystectomy for cholelithiasis with cholecystitis
  • Recorded preoperative NLR and CRP levels within 24 hours before surgery
  • Classified patients into groups based on surgical findings and histopathology for severity assessment
  • Performed correlation analysis between inflammatory markers and hospital stay duration.
  • Both NLR and CRP levels increased significantly with worsening severity of cholecystitis (p < 0.001)
  • NLR and CRP showed a strong positive correlation (r = 0.641, p = 0.001)
  • NLR correlated with longer hospital stays (r = 0.427, p = 0.001)
  • CRP also correlated significantly with longer hospital stays (r = 0.539, p = 0.001)
  • Age and BMI were not significantly linked to severity outcomes.
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Cite This Study

K et al. (2026) studied this question.

synapsesocial.com/papers/69c2298daeb5a845df0d4263https://doi.org/10.7759/cureus.105636
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