Metabolic syndrome affected 60% of patients with obstructive sleep apnea, with body mass index and apnea-hypopnea index identified as the only independent risk factors.
What is the prevalence of metabolic syndrome in patients with obstructive sleep apnea, and what factors are associated with its presence?
Metabolic syndrome is highly prevalent (60%) in patients with obstructive sleep apnea and is independently associated with higher BMI and AHI, though standard cardiovascular risk scores may not adequately capture this risk.
Background. Obstructive sleep apnea (OSA) is a highly prevalent condition. Literature has suggested the independent contribution of OSA in the pathogenesis of metabolic disturbances. Metabolic syndrome (MS), a cardiovascular risk, was frequently associated with OSA. Aims and Objectives . Evaluate the prevalence of MS in a sample of OSA patients. Identify risk factors independently associated with the presence of MS in patients with OSA. Assess compared cardiovascular risks according to the presence of MS by validated scores to demonstrate the impact of MS in these patients. Methods. Prospective study. Were included patients referred to the Pulmonology department for suspected OSA confirmed by respiratory polygraphy. All parameters needed to define the MS were collected. MS was defined according to the IDF 2005. Assessment of cardiovascular risk related to MS was performed by validated scores. Results. We recruited 50 patients with OSA. They were 53.9±11.7yr aged; 38%, males ; BMI,38.3±5.7Kg/m²; waist circumference, 117.38±12.27cm. Sixty eight per cent had comorbidities.The AHIwas49±21/h. In our study sample, the prevalence of MS demonstrated high, 60%. Logistic regression analysis identifiedBMI and AHI as only factors independently associated with MS in OSA patients. The study of scores, D'Agostino and SCORE, (respectively 21.52±17.4 (>20) and 5.54±3.49 (<5)) showed no significant difference between OSA/SM+ and OSA/SM- subgroups. Conclusion. This study demonstrate a high prevalence of MS, it would be associated with the most obese patients and severe OSA. Cardiovascular risk scores used, seem here inappropriate for the assessment of MS-releated cardiovascular risk.
Jazia et al. (2014) studied this question. Metabolic syndrome affected 60% of patients with obstructive sleep apnea, with body mass index and apnea-hypopnea index identified as the only independent risk factors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: