Key result
MDD operates as a reversible kinetic density collapse below an Axial Coherence Factor of 0.65.
Proposes a theoretical biophysics framework redefining depression as a kinetic density collapse, validated across 15 domains at a 7.3-sigma confidence level.
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Low-certainty data do not support cardiac output interventions in MDD; leaves open this biophysical framework for further study.
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REGIVALDO MOTA DE ALMEIDA (2026) studied this question. Major Depressive Disorder is a reversible kinetic density collapse operating below an Axial Coherence Factor of 0.65, validated across fifteen independent domains at a 7.3-sigma confidence level.
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