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October 1, 1986BJOG An International Journal of Obstetrics & Gynaecology

Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants

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Authors

TKT. Yee KhongFWFrank de WolfWRW.B. Robertson

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Overview

Pathological analysis reveals impaired spiral artery remodeling in pre-eclampsia and fetal growth restriction, indicating defective trophoblast invasion into uterine tissues.

Key Points

  • To assess maternal vascular adaptations and spiral artery structural changes within the placental bed during pregnancies complicated by pre-eclampsia and small-for-gestational age infants.
  • Histological examination of the placental bed assessing physiological vascular changes extending from the decidua into the inner myometrium.
  • Comparative analysis of basal plates of placentas obtained from normal pregnancies, pre-eclamptic pregnancies, and pregnancies resulting in small-for-gestational age infants.
  • Physiological remodeling of spiral arteries is restricted solely to decidual segments or completely absent in pre-eclampsia and small-for-gestational age pregnancies, failing to extend into the myometrium.
  • Intraluminal endovascular trophoblast persists into the third trimester within placental bed spiral arteries in pre-eclampsia and small-for-gestational age cases, unlike normal pregnancies where it resolves after the second trimester.

Cite This Study

Khong et al. (1986) studied this question.

synapsesocial.com/papers/69c30281a77124f241cab4fahttps://doi.org/10.1111/j.1471-0528.1986.tb07830.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FETAL GROWTH RETARDATION AND THE MATERNAL ARTERIAL SUPPLY OF THE HUMAN PLACENTA IN THE ABSENCE OF SUSTAINED HYPERTENSION1980 · 173 citations
  2. 2Clinical Perinatology1975 · 5 citations
  3. 3MORPHOLOGICAL CHANGES OF THE SPIRAL ARTERIES IN THE PLACENTAE BED IN RELATION TO PRE‐ECLAMPSIA AND FETAL GROWTH RETARDATION1981 · 370 citations