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March 25, 2026BMC Veterinary ResearchOpen Access

Molecular characterization of rabbit hemorrhagic disease virus type 2 and long-lasting protection conferred by a VLP-based vaccine

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Authors

YWYanhui WangLuoyang Cement Engineering Design and Research InstitutePQPeipei QiaoLuoyang Cement Engineering Design and Research InstituteHWHongchao WuLuoyang Cement Engineering Design and Research Institute

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Implication

Investigation reports long-lasting protection against rabbit hemorrhagic disease virus in rabbits using a VLP vaccine, suggesting a robust immunization strategy.

Key Points

  • The aim is to characterize RHDV type 2 and evaluate the efficacy of a novel VLP-based vaccine.
  • Collected 205 clinical samples from 16 cities in China between 2020-2024.
  • Sequenced the VP60 gene from 18 RHDV-2 positive samples to determine genetic characteristics.
  • Developed a recombinant baculovirus to express the VP60 protein and assessed its immunogenicity in rabbits.
  • 86 samples tested positive for RHDV-2 with over 95% nucleotide identity to the reference strain.
  • VLP vaccine induced specific antibodies in rabbits, leading to a 100% survival rate against various RHDV2 strains.
  • Protection lasted for at least 180 days post-vaccination.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69c37adcb34aaaeb1a67cb9chttps://doi.org/10.1186/s12917-026-05374-2
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