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March 25, 2026BMJ Mental HealthOpen Access

Discontinuation and reinitiation of pharmacological treatment for ADHD among individuals with ADHD and substance use disorder

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Authors

ACAndrea Johansson CapusanLZLe ZhangHLHenrik Larsson

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Overview

Matched cohort study explores ADHD treatment discontinuation in individuals with comorbid SUD, indicating reduced treatment continuity.

Key Points

  • This study aims to investigate the impact of substance use disorder on the discontinuation and reinitiation of ADHD medication among individuals with ADHD.
  • Used a matched cohort design with 9283 individuals with ADHD and SUD in Sweden from 2006 to 2020.
  • Matched controls with ADHD but no SUD (n=46,401) on sex and birth year in a 5:1 ratio.
  • Estimated hazard ratios for discontinuation and reinitiation using stratified Cox models.
  • Individuals with ADHD and SUD were nearly twice as likely to discontinue treatment within one year (HR: 1.99).
  • Those with ADHD and SUD were less likely to reinitiate treatment after discontinuation (HR: 0.82).
  • Factors associated with discontinuation included male sex, adolescent to young adult age, and lower stimulant doses.

Cite This Study

Capusan et al. (2026) studied this question.

synapsesocial.com/papers/69c37afeb34aaaeb1a67d06ehttps://doi.org/10.1136/bmjment-2025-302138
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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